David Arquette was married to co-star Courteney Cox Arquette. They met on the set of Scream, began dating during production of Scream 2 and had arrived back from their honeymoon just in time for filming of Scream 3. They separated in 2010 shortly after filming of Scream 4 had ended.
When asked about the future of the series after the release of Scream 4 in an interview, David Arquette has expressed doubts about the possibility of a fifth Scream film. However, he has admitted to deeply enjoying the role of Deputy Dwight 'Dewey' Riley.
He and Courteney made their own motion film production company named Coquette Productions.
David Arquette's character Dewey is specified as being 25 years old, approximately 7 years older than most other lead characters who are in high school. However, Arquette is roughly the same age as most of his costars and is actually slightly younger than Skeet Ulrich, Matthew Lillard and Jamie Kennedy, who all portray themselves as high school students.