Johnny Simmons, Tiya Sircarm, and Alex Sander are all possibly candidates to appear in Scream 5. 
Paul Maso is rumored to play a character named David 
Although not a confirmation, Dimension Films did tweet the following on December 1, 2011: "Which Dimension Films sequel are you most looking forward to? #Piranha3DD, #ScaryMovie5, #HalloweenIII , #Scream5" This has given many fans a new hope that a fifth movie is going to be made.
Still no official confirmation, though Dimension Films is definitely teasing the fans. On December 6, 2011, they tweeted the following: "Which #5 are you looking forward to more? Scream 5 or Scary Movie 5?"